UTILIZING DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING (DCE-MRI) TO ANALYZE INTERSTITIAL FLUID FLOW AND TRANSPORT IN GLIOBLASTOMA AND THE SURROUNDING PARENCHYMA IN HUMAN PATIENTS

Utilizing Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Analyze Interstitial Fluid Flow and Transport in Glioblastoma and the Surrounding Parenchyma in Human Patients

Background: Glioblastoma (GBM) is the deadliest and most common brain tumor in adults, with poor survival and response to aggressive therapy.Limited access of drugs to tumor cells is one reason for such grim clinical outcomes.A driving force for therapeutic delivery is interstitial fluid flow (IFF), both within the tumor and in the surrounding brai

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Biopterin metabolism and nitric oxide recoupling in cancer

Tetrahydrobiopterin is a cofactor necessary for the activity of several enzymes, the most studied of which is nitric oxide synthase.The role of this cofactor-enzyme relationship in vascular biology is well established.Recently, tetrahydrobiopterin metabolism has received increasing attention in the field of cancer immunology and immunotherapy due t

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Evaluation of the harmonization process of the Czech insurance market with the single insurance market of the EU

For the Czech insurance industry, it has been 13 years since the passage of the Insurance Act in 1991, which did away with the monopoly and allowed competition in this business sector.In our evaluation, we can state that the positives outweigh the negatives.A relatively high pace of growth in total premiums written ivoryjinelle.com was achieved and

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